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The authors noted the limitations of their small patient population, but they emphasized that although many studies confirm the increase in serum BDNF levels after ECT, there is also a large group of studies confirming their observations that reported no effect of ECT on serum or plasma BDNF levels during or after the ECT series

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100,101,102 A similar biphasic pattern occurs in MASLD: mitophagy is enhanced during early disease to counteract lipid excess and maintain mitochondrial homeostasis, but prolonged metabolic stress suppresses this adaptive response