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One successful example is demonstrated by a newly developed AMP named D8 with a designed substitution of d-Val for l-Val of engineered cationic AMP WLBU2, which resulted in increased resistance to protease enzymatic degradation, higher activity against bacterial biofilm, noticeably lower cytotoxicity to erythrocytes and white blood cells, and increased safety in mice compared to the original WLBU2 (292)