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Treponema pallidum and its membrane protein Tp47 induced microglial activation and apoptosis, while disrupting autophagic flux via the mechanistic target of rapamycin complex 1/transcription factor EB (mTORC1/TFEB) pathway, with concurrent modulation of PI3K/Akt/forkhead box O1 (FOXO1) signaling (306, 308)

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