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A 2019 ultrasound study (Gibney et al., Diabetes Obesity and Metabolism ) measured actual needle-tip placement in 240 subcutaneous injections and found that the "always 45 degrees" rule produced correct placement in only 64% of injections

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Glutathione is the most abundant non-protein thiol (compounds containing R-SH) in animal cells, with concentrations ranging from 0.5 to 10 mmol/L

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