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We transduced primary hepatocytes with a recombinant adenovirus expressing NHK in a doxycycline (Dox)-inducible manner (Ad-TetOn-NHK)

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RT-induced salivary gland dysfunction results in hyposalivation (i.e., measured reduction in saliva production), xerostomia (i.e., the sensation of oral dryness), mucositis, nutritional deficiencies, oral infections and functional changes, such as difficulties with mastication, dysphagia (i.e., problems with swallowing) and loss of taste, which can significantly reduce the quality of life for afflicted patients [10,11]