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A decrease in GSH is attributed to various factors, including inactivation of GR by disulfide bond formation and protein unfolding, decreased de novo synthesis, its use in detoxification, increased breakdown, or the failure to regenerate GSH from the oxidized form of GSSG [119, 120]

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CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers