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Mechanistically, augmented ischemia-reperfusion injury in the absence of GPx-1 may be caused by increased NFκB activation, as pyrrolidine dithiocarbamate (PDTC), an NFκB inhibitor, partially protects against neurotoxicity in this model (82)

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Older adults sit at higher baseline risk, with reported dehydration rates of around 17–28% in the US population