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Afferent fibers are divided into intra-intestinal and extra-intestinal fibers, with intra-intestinal fibers responding to the mechanical movement, distension, and changes in chemical composition at the receptors in the walls of the gastrointestinal tract, as well as the extra-intestinal fibers responding to the mechanical movement, distension, and changes in chemical composition at the receptors in the pancreas, liver, portal vein, and lungs