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Of note, in STEP 3 intensive behavioral treatment was also administered in both arms, and in STEP 4 all patients were initially assigned to semaglutide 2.4 mg but were randomized 2:1 to semaglutide 2.4 or placebo after 20 weeks 25

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Endothelial-specific telomerase inactivation causes telomere-independent cell senescence and multi-organ dysfunction characteristic of aging