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It does not occur independently in nature — it is produced through solid-phase peptide synthesis in the laboratory

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One of the main effects of insulin on the adipose tissue and the skeletal muscle is to increase glucose uptake, which is mediated by the increase in vesicular trafficking of the glucose transporter-4 (GLUT4) from intracellular compartments to the plasma membrane, resulting in insulin-stimulated glucose uptake (ISGU) (87)