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GO term analysis for genes downregulated ≥ 2-fold compared to control conditions showed that both H 2 O 2 and t-BHP downregulated genes involved in DNA replication, t-BHP downregulated genes involved in chromosome regulation, and H 2 O 2 downregulated genes involved in RNA processing (Fig 9D and 9E)

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Currently, many unresolved issues remain in the field of ferroptosis research