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In a D-galactose-induced aging model, CRO improves cognitive function via its anti-glycation and antioxidant activities, thereby suppressing the expression of neuroinflammatory mediators (e.g., IL-1β, TNF-α, and NF-κB) and activating the PI3K/Akt and ERK/MAPK signaling pathways (Looti Bashiyan et al., 2021)