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There is robust evidence indicating that the activation of the NF-κB signaling pathway enhances the expression of ECM components and contributes to apoptosis in NP cells, consequently facilitating the progression of IDD (166, 167)

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Intriguingly, a Western diet high in PUFAs can induce intestinal inflammation in mice lacking one allele of GPX4 in IECs, which implies that dietary PUFAs may be a trigger of GPX4-restricted mucosal inflammation phenocopying aspects of human CD (143)