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Deletion of the whole helix 73 would be the final step in dissecting the SymR from the LSU rRNA

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The functionally active form of thiamine is thiamine pyrophosphate which is involved in the metabolism of carbohydrates as dehydrogenases factor (ketoacidotic branched chain dehydrogenase complex piruvatodeshidrogenasa or alpha-ketoglutarate dehydrogenase) and transcetolasas