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The N-methylhistamine is further broken down with the MAO-B enzyme, forming N -methylimidazole acetaldehyde.[ref] Histamine (from body cells) → [HNMT enzyme] → N-methylhistamine → [MAO-B enzyme] → N-methylimidazole acetaldehyde Note that the HNMT enzyme (histamine N-methyltransferase) facilitates the transfer of a methyl group in the breakdown of histamine through this pathway