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They act on two different receptors that converge on the same outcome, which is why pairing them produces a more complete signal than either one alone

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Very recently, sorafenib-glucuronide has been shown to display in UGT enzyme - efflux transporter (MRP2/MRP3) - uptake transporter (OAPT1B1/1B3) coupling, hepatocyte shuttling/hopping, as well as enterohepatic recycling (Vasilyeva et al., 2015)