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In addition, although PKC activation is acknowledged to have variable effects on GABA A Rs 64 , the enhancement of inhibitory synaptic currents through PKC-dependent phosphorylation and the regulation of GABA A R clustering by the phosphorylation of the γ2 S327 site are also well established 26,44,45,56,59,65

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Coadministered cagrilintide and semaglutide in adults with overweight or obesity