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In the field of aging research, hallmarks of aging have been established including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intracellular communication (López-Otín et al., 2013)

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The spherule outer wall glycoprotein (SOWgp) is an important, immunostimulatory glycoprotein expressed on the surface of the Coccidiodes spherules and endospores (Hung et al