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the functioning of the patient returns to or remains normal (as assessed in comparison to suitable control subjects or standardized values obtained therefrom), this need not always be the case

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Exercise, as a critical adjunct to pharmacological therapy, has been extensively shown to confer multiple therapeutic benefits in NDDs, including suppression of neuronal ferroptosis, mitigation of neuroinflammation, reduction of Tau hyperphosphorylation, and enhancement of cognitive performance (Gutierre et al., 2025)