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According to previous research ( in vitro , the levels of Tumor necrosis factor ligand superfamily member(TNF)-α, IL-8, and IL-1β in the cell supernatant were greater than in the control group ( Inflammation and oxidative stress are interrelated, and increases in oxidative stress can cause acute and chronic inflammation ( 4.3 EMS influences GCs steroid hormone production The synthesis and secretion of steroid hormones by GCs is critical for follicular growth and, as a result, can impact the quality of oocytes

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Importantly, as the chief brain source of APOE, astrocytes, especially those expressing the APOE4 allele, promote Aβ aggregation, tau pathologies, BBB breakdown, and cerebrovascular dysfunctions (Wang M