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Histone demethylation requires Jumonji C-domain-containing histone demethylases, which are also ascorbate-dependent 2-ODDs, thereby providing a further means for ascorbate to influence gene expression [129], [139]

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Out of 12 patients, 7 reported subjective improvement in symptoms for more than 6 months following intraarticular injection of BPC-157 alone (2 cc of 2000 mcg/mL solution) [25]

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