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However, the association between the GRK4 variants and hypertension was not found in other studies, which may be age/sex/race/ethnicity-related, or a failure to study all the GRK4 variants [103, 109, 111,112,113,114]

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Apart from ROS being created as a result of oxidative glucose metabolism, the constant exposure of retinal cells to sunlight and artificial light triggers the production of ROS 16,17 , especially with photosensitizers present, such as retinoids 16,18 , and leads to photo-oxidation 19