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Expression of the A315T mutant TDP-43 in vitro decreased GSH levels and increased both ROS and cell death, while the restoration of GSH levels by treatment with GSH monoethyl ester prevented cell death and TDP-43 pathological changes in motor neurons [118]
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These enzymes catalyze the conjugation of glutathione with various toxins, including: Pesticide residues Industrial chemicals Alcohol metabolites Prescription drug byproducts Step 3: Sulfation Support Glutathione provides sulfur groups needed for sulfation, another crucial phase II detoxification pathway