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erythrocateresis), the action of HO-1 takes on pathological significance in various diseases, and abnormal CO metabolism has been observed in cancer, hematological diseases, hypertension, heart failure, inflammation, sepsis, neurodegeneration
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441,442 Infliximab is an IgG1 mouse-derived monoclonal antibody specific for TNFα, 443 which was approved by the FDA for the treatment of psoriatic arthritis and plaque psoriasis in 2005 and 2006, respectively
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