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Acta Obstet Gynecol Scand 2007;86(2):145–50

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Exploration and integration of novel delivery strategies Although prodrug-based, nanocarrier-based, protein-based and polymer-based delivery systems significantly improve the bioavailability of PROTAC and provide important strategies to overcome inherent limitations, such as high molecular weight, low cell permeability, out-target effects and unfavorable pharmacokinetic properties