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Results showed a significant reduction in CD34-positive staining in the placenta of Coq4 −/− mice compared to WT mice, indicating markedly decreased neovascularization (Figure 1B)

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Matrix metalloproteinases (MMPs), including collagenases (MMP1, MMP8, MMP13) and gelatinases (MMP2, MMP9), play a significant role in ECM degradation, with MMP12 also contributing

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