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doi: 10.1016/j.jdcr.2024.05.035

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GSH biosynthesis is transcriptionally controlled by NRF2, one critical oxidative stress-induced transcription factor being capable of promoting transcription of multiple antioxidant genes, including GCL(GCLC/GCLM), glutathione synthetase (GSS), and a subunit of the cystine/glutamate transporter xCT (SLC7A11) indispensable for GSH synthesis, as well as other redox enzymes utilizing GSH or NADPH to reduce the oxidized substrates, such as GPX4 [27, 28]