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If irregularities in the posterior border of the vitreous base arise from this process, there is a predisposition towards retinal break formation during posterior vitreous detachment and subsequent rhegmatogenous retinal detachment

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as well as insulin receptor substrate 1 (IRS-1) inhibitors, PI3K inhibitors, and mTOR inhibitors alone or in combination ( Interestingly, various reports, including a study aimed at developing new insulin analogues thermally more stable and with more physiological profiles than human insulin provided evidence for the possibility to develop IR-A/IGF-1R targeting agents with higher specificity ( 6.3 Cancer resistance to anti-IGF-1R therapies A body of literature has reported evidence of resistance to anti-IGF-1R therapies