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Moreover, mutations in specific C-terminal leucine residues of GIRK1 altered channel properties without affecting Gβγ binding, indicating their role in modulating Gβγ-induced changes in channel gating (Ivanina et al., 2003)

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In NSCs, depletion of growth factors triggers cytoplasmic Ca 2+ release followed by mitochondrial Ca 2+ uptake, which enhances mitochondrial ROS production