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Clinical chemistry and haematological parameters were investigated in groups of 8 to 10 male or female Sprague-Dawley rats exposed to 0, 20, 40, 202 or 1012 mg/m 3 (decreased to 607 mg/m 3 after several days) (0, 5, 10, 50 or 250/150 ppm), 7 h/day, 5 days/week for 3, 6, and 18 months, beginning at 3 months of age