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Then, pro-inflammatory factors cross the blood-brain barrier (BBB) into the brain through blood circulation, activating microglia, releasing reactive nitrogen and oxygen, and damaging brain epithelial cells leading to neuroinflammation, which can lead to mental illness (Peirce and Alviña, 2019
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Identification of the clinical development candidate mrtx849, a covalent krasg12c inhibitor for the treatment of cancer
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