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Additionally, the inflammatory microenvironment is an important factor influencing the regeneration of cartilage tissue, which can inhibit the differentiation of MSCs such as chondrocytes, leading to chondrocyte death and hypertrophy, extracellular matrix decomposition, and even promoting the progression of osteoarthritis [436]

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However, lowering of hemoglobin and hematocrit was not observed in the 28 day study using oral delivery of NBMI at 1.0 g kg −1 body weight demonstrating that Fe 2+ was not depleted (Table 2)