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In this context, small amounts of ROS can trigger an adaptive response that enhances the body’s defense mechanisms, delaying the onset of aging-related diseases and potentially extending the overall lifespan [108]
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Subsequent studies have shown that one of the core lipid peroxidation products, 4-HNE, is markedly upregulated in lung fibroblasts derived from patients with pulmonary fibrosis (Reyes-Jiménez et al., 2021)
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