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The mechanism by which interferon-γ (IFNγ) released by CD8 + T cells exerts its effects involves the downregulation of SLC3A2 and SLC7A11, two subunits of the glutamic acid-cystine antitransporter system Xc -
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The aggregation of the mutated HTT gene triggers neuronal cell death through the apoptotic pathway, which mainly results from mitochondrial dysfunction [166,169]—one of the important mechanisms involved in the pathology of HD [2,23,170]
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