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The cryo-EM maps and structure data have been deposited in the Electron Microscopy Database and PDB (EMD-49361 86 ( EMD-49362 87 ( PDBID 9NFB 88 ( and PDBID 9NFC 89 (
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The rationale for injectable use rests on pharmacokinetic reasoning, the superior systemic bioavailability argument, and extrapolation from topical efficacy data
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