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Disruption of its function has been identified in several neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and prion diseases, as well as in amyotrophic lateral sclerosis (ALS)
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Specific opioid receptors are expressed in many neuronal populations, with a distribution in the central nervous system (CNS) that closely corresponds to sites of opioid action deduced from the effects of local agonist and antagonist infusion
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