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This section mainly introduces the key regulator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (Peroxisome-proliferator-activated receptorγcoactivator-1α, PGC-1α), nuclear respiratory factor (Nuclear respiratory factors 1/2, NRF1/2), mitochondrial transcription factor A (Mitochondrial transcription factor A, TFAM) mediates the regulatory mechanism of mitochondrial biogenesis (Figure 2)

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