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However, it’s important to keep the following in mind: ALA is not a substitute for statins or other prescription cholesterol medications The lipid-lowering effect is generally modest, especially in healthy individuals or those already on treatment Dose and duration matter — most benefits are seen at 600–1,200mg/day over 8+ weeks Antioxidant and anti-inflammatory effects: moderate evidence ALA is best known for its antioxidant activity — and that’s not just in theory
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In contrast, in an ex vivo experimental study of acute lung inflammation in mice exposed to aerosol endotoxin (LPS), there was a significant reduction of oxygen radicals in neutrophils obtained from BAL fluid with dexamethasone but not NAC, demonstrating a differential anti-oxidative effect of the two drugs [79]
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