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As one of the major producers of ROS, mitochondria are particularly vulnerable to oxidative stress-induced cytotoxicity, especially considering mtDNA is not protected by histone proteins as seen in nuclear DNA (Richter et al., 1988)
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Indeed, UBX0101 treatment on aged mice with post-traumatic OA after surgery reduces the presence of senescent cells, improves articular cartilage, and upregulates the expression of genes involved in new cartilage growth 25
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