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361,362,363 Proton magnetic resonance spectroscopy studies have shown a reduced N-acetylaspartate to creatine ratio in the thalamus and parietal white matter pathways of DPN patients, indicating neuronal dysfunction

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Strict humane endpoints mandated euthanasia via CO 2 asphyxiation/cervical dislocation if tumors reached 2000 mm 3 or exhibited severe morbidity (post-mortem pupillary reflex confirmation)