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SARS-CoV-2 S-protein shows varying states of conformational shifts of the RBD site progressing towards proteolytic processing, making the viral RBD more accessible to ACE2, with the cleavage at the S1/S2 leading towards RBD open confirmation and viral internalization [33, 34]

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However, the heart rate-lowering effect of compound 34 did not significantly differ from that of adenosine