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The resulting treatment strategies mainly include targeting the crosstalk between the CNS and the peripheral immune system (using drugs such as fingolimod, etanercept, minocycline), activation of AhR (using laquinimod, Lactobacillus reuteri ), fecal microbiota transplantation and probiotic intervention, which may provide new therapeutic strategies for brain injury after IS and reduce the poor prognosis of IS patients