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However, cysteine residues modified by MMTS and endogenous disulphides are also reduced to form free thiol during this elution step ( S -NO PTMs ( Another BST-based approach, SNO TRAP ( S -NO trapping by triaryl phosphine) was developed to selectively target S -nitrosylated proteins to reveal those involved in the early stages of neurodegeneration in a mouse model of Alzheimer’s disease (Seneviratne et al., 2016)