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Treatment of TN involves a multifaceted approach that considers patient-specific factors, including the type of TN, with initial pharmacotherapy followed by surgical options if necessary

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Alternatively, 13 C NMR analysis (Section 5) and activity-based protein profiling (Section 6) require chemical modification of the covalent ligand to enable detection of the covalent protein–drug adduct (e.g., introduction of a bioorthogonal handle, reporter tag, or isotope labeling)