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Within seconds of the sensing of increased reactive oxygen species (ROS), several enzymes of glycolysis (particularly glyceraldehyde-3-phosphate dehydrogenase and pyruvate kinase) are inhibiting allowing for the diversion of glucose carbons into the PPP
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On one side, sulfasalazine inhibits cystine uptake and decreases GSH and GPX4 levels by inhibiting the system Xc −
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