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These mutations in SHP2 result in hyperactive phosphatase activity, notably with elevated basal activity and result in inhibition of GH-induced insulin-like growth factor-1 (IGF-1) production (143, 151)
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In case of failure of these antioxidant enzymes, H 2 O 2 can also be reduced to hydroxyl radical (OH − ), the most harmful free radical for biological systems, due to its high reactivity
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