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DNA methylation principally occurs in the fifth carbon of cytosine residues (addition of a methyl or hydroxymethyl group, denoted as 5mC or 5hmC, respectively) in DNA sequence and mostly at cytosine-phosphate-guanosine (CpG) dinucleotides and to a lesser extent at cytosine-phosphate-adenosine (CpA), cytosine-phosphate-thymine (CpT), and cytosine-phosphate-cytosine (CpC) dinucleotides
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