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The best binding poses for both substrates had a highly similar conformation to (−)-catechin ( 12 ), with an RMSD of matched atoms of 0.51 Å for flavan-3,3,4-triol ( 4 ) and 0.54 Å for flavan-3-on-4-ol ( 7 )

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(D) aILC2s were lysed post 24h incubation with and without melatonin and the quantity of β-hydroxybutyrate in each lysate was quantified