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43,44 A couple of uncontrolled studies in healthy volunteers showed significant homocysteine-lowering effects of acute administration of NAC, 7200 mg within 24 hours, 45 and 1200−4000 mg once, 44 with average reductions of 44% and 22%, respectively

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High oxidative stress can lead to the oxidation of LDL cholesterol, transforming it into oxidized LDL, which is more atherogenic