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The weight gain in HFD-fed rats is likely attributed to the consumption of diets enriched in saturated fats, such as lard, resulting in a significant increase in dietary energy intake

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NOX enzymes are activated by diverse mediators, including PDGF [78], angiotensin II [79], leptin [80, 81], alcohol [82], and phagocytosis of apoptotic hepatocyte bodies [83]